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Some of Dr. James I. Bicher 's (Haim I. Bicher, James Bicher, Haim Bicher) latest publications.
1. Bicher HI MD. Protracted Thermoradiotherapy, treating to effect with objective end points. Proceedings of the XXV ICHS Destin, Florida, USA, October 16th-19th, 2002
2. Bicher HI MD, Mitagvaria NP PhD, Nebieridze MI MD. Local Hyperthermia treatment results in significant morphological changes in rats’ brain tissue. Proceedings of the XXVI ICHS Shenzhen, China, September 10th-12th, 2004.
3. Bicher HI MD. Thermoradiotherapy Treatment of malignant tumors. Fractionation regime and objective end points. An update. Proceedings of the XXVI ICHS Shenzhen, China, September 10th-12th, 2004.
4. Bicher HI MD., Al-Bussam N MD; Wolfstein, RS. M.D Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Proceedings of the XXVII ICHS Florence, Italy, October 27th – 28th, 2005.
5. Bicher HI MD., Al-Bussam N MD; Wolfstein, RS. M.D Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Deutsche Zeitschrift für Onkologie (German Journal of Oncology) 2006, 38: 116-122. Haim Bicher, M.D. paper, presented in the 2007 International Clinical Hyperthermia Society (ICHS), Mumbai, India, January 4th and 5th. The Role of Local Blood Flow, Rheological Properties and Free Radicals in Hyperthermia-Induced in Cerebral Tissue Damage
Haim I. Bicher, Nodar P. Mitagvaria*, Marina I. Nebieridze*
Valley Cancer Institute, Los Angeles, California, USA *Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia
Objective. We tried the sensitivity of cerebral tissue to hyperthermia as manifested by histological changes and the role of local blood flow, blood rheological properties, and free radicals in development of mentioned changes. .Research design and methods. Local areas of cerebral surface were irrigated by artificial cerebrospinal fluid heated up to the temperature necessary for achievement of stable level of temperature (41, 43 or 450C). Serial brain coronal sections 50 mm thick stained with Azure-Eosin were analyzed under light microscope. The local cerebral blood flow was measured by thermal clearance method. Blood rheological properties were changed by injection of high molecular weight Dextran T-500 and free radicals existence was controlled by Dimethyl sulfoxide injection. Results. At 410C just superficial lesions of the cerebral cortex and a few cases of thrombosed cerebral microvessels have been observed. The rise of temperature on 20C resulted in very severe lesions of cerebral tissue; the layered structure of the cerebral cortex in the central parts of the hyperthermia–induced lesions was impaired. The highest temperature (450C) caused complete destruction of the layered structure of the cortex in the area of hyperthermic exposure, numerous areas with lost neurons and thrombosed cerebral vessels with perivascular accumulation of erythrocytes were revealed. Injection of Dextran T-500 resulted in deterioration and injection of Dimethyl sulfoxide in significant improvement of histological changes in cerebral tissue when 43 or 450C hyperthermia is used. Bi-phase alterations of local cerebral blood flow have been revealed at 430C hyperthermia. Pronounced hyperemia in first stage of heating is followed by remarkable ischemia on the late stage. Conclusion. High sensitivity of cerebral tissue to hyperthermic exposure has been confirmed. We can consider cerebrovascular thrombosis as one of the most significant complication of brain hyperthermia. In case of deteriorated blood rheological properties hyperthermia-induced cerebral lesion is more remarkable. Administration of antioxidants, scavengers of free radicals can partially lessen hyperthermia induced cerebral lesion. Search Engine Optimization by SeOS
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Revised: 10/11/07. |
